Services

Keck Genomics Platform Services Overview

At the Keck Genomics Platform (KGP) of USC, we provide comprehensive sequencing services designed to support a wide array of research projects. Our technology and staff ensure high-quality data and customizable solutions for various genomic applications. Below, you will find detailed information about our sequencing services.

Sequencing Services

Whole-Genome Sequencing (WGS)

Our Whole-Genome Sequencing service includes sample quality control (QC), library preparation, and deep coverage sequencing. This service is scalable to meet the specific needs of your project.

Whole-Exome Sequencing (WES)

Exome sequencing focuses on the coding regions of the genome, capturing 40-65 Mbp of exonic sequences. It offers a cost-effective alternative to whole-genome sequencing while maintaining high specificity and coverage. This service is ideal for detecting variants in coding regions efficiently.

RNA-Seq (Total Transcriptomic, mRNA by Poly-A Pulldown, and mRNA by Enrichment)

RNA-Seq services at KGP allow researchers to analyze the transcriptome, providing insights into gene expression, gene fusions, alternative splicing, and novel transcripts. Standard coverage ranges from approximately 20-50 million paired-end reads, with our standard offering being 35 million paired-end reads (70 million total), customizable to your project’s needs.

Targeted Sequencing and Custom Enrichment

We offer targeted gene enrichment panels to isolate specific genomic regions, providing a cost-effective method for detecting germline and somatic mutations. Our predefined cancer panels cover over 300 cancer-related genes with high specificity and deep coverage. Additionally, custom gene panels can be designed to align with your unique project requirements.

Whole-Genome-Bisulfite Sequencing

For researchers focused on epigenetics, our Whole-Genome Bisulfite Sequencing service enables comprehensive analysis of DNA methylation patterns across the entire genome.

Custom Sequencing Services

We also accommodate pre-made Illumina-compatible libraries, providing flexible sequencing options on our NovaSeq and MiSeq platforms.